The PaGeR Study: Using Multiplex Families to Map Genes that Modify Susceptibility and Age at Onset in Parkinson’s Disease

The purpose of the PaGeR Study is to identify genes that increase a person's risk of developing Parkinson's disease (PD) or a related disorder. For people who already have PD, the study is also trying to find genes that increase the likelihood of developing certain PD-related problems such as difficulties with thinking and memory. In this study, we will compare differences in genes between patients with PD, their family members, and unrelated people who do not have PD (controls). In some instances we might also examine how differences in certain genes relate to differences in proteins found in blood. This study consists of one visit that includes a blood draw, neurological assessments, and questionnaires. All unaffected family members are being asked to participate as well.